TABLE 3.
Summary of minimal inhibitory drug dilutions and AEs of topical ocular drugs
| Drug | Minimal inhibitory dilution | AE |
|---|---|---|
| Proparacaine (anesthetic) | 1/1 | 100.1 |
| Prednisolone (steroid) | 1/1 | 91.2 |
| Bromfenac (nonsteroidal) | 1/1 | 97.4 |
| Nepafenac (nonsteroidal) | 1/10 | 95.0 |
| Gatifloxacin (antibiotic) | 1/10 | 92.6 |
| Moxifloxacin (antibiotic) | 1/10 | 92.0 |
| Tobramycin (antibiotic) | 1/1 | 102.9 |
| Cefazolin (antibiotic) | 1/10 | 91.6 |
| Amphotericin B (antifungal) | 1/1 | 108.7 |
| Trifluridine (antiviral) | 1/40a | 94.6 |
| Propamidine (antiacanthamoebic) | 1/10 | 85.7 |
| Polyhexamethylene biguanide (antiacanthamoebic) | 1/640b | 72.7 |
| Chlorhexidine (antiacanthamoebic) | 1/10 | 77.0 |
| Corneal tissue | 1/1 | 86.9 |
a
Trifluridine inhibition was removed completely after DNA extraction (1/1).
b
Polyhexamethylene biguanide inhibition was still present after DNA extraction (the minimal inhibitory dilution improved onefold to 1/320).