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An example of MIRU-VNTR (Mx) and IS6110 RFLP (ISx) genotypes. The connecting lines represent the MIRU-VNTR and IS6110 RFLP genotype combinations observed in M. tuberculosis isolates in the study setting. M1 and M2 are both linked to IS1 and IS2 and therefore represent a convergent event. Neither M3 nor M4 share common connections to more than one ISx with any other Mx. Their connecting lines therefore indicate simple, linear evolution.
