FIG. 2.

Reduced inflammatory pathology and infiltrates in the CNSs of anti-TNF-α treated CXCL10^−/− mice. Following Depo-Provera treatment, CXCL10^−/− mice (n = 3/group) were infected with HSV-2 (2,000 PFU/vagina). On day 5 postinfection, 100 μg of anti-mouse TNF-α or isotypic control Ab was administered retro-orbitally into HSV-2-infected CXCL10^−/− mice. On day 7 postinfection, mice were exsanguinated and the brain stems and spinal cords were removed from each mouse and processed for histological analysis following hematoxylin and eosin staining. Tissues from uninfected CXCL10^−/− mice were used as a control. Magnification, ×400.