Table 3.
Selected UCR Motifs
| Proportion of UCRs with Motif | Median Motifs per UCR | ||||||||
| Motif | FET p value | BH | Enriched over genome? | miRNA | siRNA | PIWI | miRNA | siRNA | PIWI |
| NFkB2 | not sig.^ | not sig. | No | 0.188 | 0.250 | 0.100 | 1.0 | 1.0 | 1.0 |
| NFkB4 | not sig. | not sig. | No | 0.313 | 0.438 | 0.460 | 1.0 | 1.0 | 1.0 |
| NFkB7* | not sig. | not sig. | No | 0.188 | 0.375 | 0.280 | 1.0 | 1.0 | 1.0 |
| BRC_Z1 | not sig. | not sig. | No | 0.813 | 0.313 | 0.540 | 1.0 | 1.0 | 1.0 |
| BRC_Z2 | not sig. | not sig. | No | 0.563 | 0.688 | 0.620 | 1.0 | 1.0 | 1.0 |
| Pathway-specific | miRNA | siRNA | PIWI | ||||||
| M19 (miRNA) | not sig. | not sig. | Yes | 0.188 | 0.100 | 0.033 | 4.5 | 1 | 1 |
| M21 (miRNA) | not sig. | not sig. | Yes | 0.219 | 0.100 | 0.067 | 2 | 2 | 1 |
| M24 (siRNA) | not sig. | not sig. | Yes | 0.063 | 0.400 | 0.200 | 1 | 14 | 1 |
| M26 (siRNA) | not sig. | not sig. | Yes | 0.031 | 0.250 | 0.033 | 2 | 3 | 2 |
| M30 (PIWI) | not sig. | not sig. | Yes | 0.000 | 0.000 | 0.060 | NA | NA | 5 |
| Species-Specific | Aae | Aga | Cpi | Aae | Aga | Cpi | |||
| M1 (Aedes) | not sig. | not sig. | Yes | 0.188 | 0.100 | 0.033 | 1.5 | 1.5 | 1 |
| M2 (Aedes) | not sig. | not sig. | Yes | 0.219 | 0.100 | 0.067 | 2 | 2 | 1 |
| M3 (Aedes) | not sig. | not sig. | Yes | 0.094 | 0.000 | 0.033 | 9 | NA | 1 |
| M7 (Anopheles)# | not sig. | not sig. | Yes | 0.063 | 0.400 | 0.200 | 10.5 | 1.5 | 1 |
| M8 (Anopheles) # | not sig. | not sig. | Yes | 0.031 | 0.250 | 0.033 | 10 | 1 | 1 |
| M9 (Anopheles) | < 0.001 | 0.002 | No | 0.000 | 0.400 | 0.300 | NA | 6 | 1 |
| M12 (Culex)+ | not sig. | not sig. | Yes | 0.031 | 0.000 | 0.067 | 1 | NA | 21 |
| M13 (Culex)+ | not sig. | not sig. | Yes | 0.031 | 0.000 | 0.067 | 1 | NA | 21 |
| M17 (Culex) | < 0.001 | 0.002 | No | 0.094 | 0.100 | 0.533 | 1 | 1 | 1 |
"^", see Additional File 4 for details. "*", for NFkB7 only, significance scores were based on the presence of 2 or more hits per UCR. "#", enriched in an siRNA pathway specific manner. "+", enriched in an miRNA pathway specific manner. "BH", Benjamini-Hochberg test, cut-off = 0.05. "FET", Fisher's Exact test, cutoff = 0.01. "NA", not applicable. "Aae", Ae. aegypti, "Aga", An. gambiae, "Cpi", Cx. pipiens.