Table 2.
Baseline characteristics (mean (standard deviation), or percent) of the ARIC cohort stratified by menopausal and exposure status
| Characteristic | Pre-menopausal (n=2,217) |
Post-menopausal (n=4,441) |
||||
|---|---|---|---|---|---|---|
| Exposure status | Exposure status | |||||
| Total | Exposed (n=735) | Unexposed (n=1,482) | Total | Exposed (n=1,582) | Unexposed (n=2,859) | |
| (HDL-C<50 mg/dL) | (HDL-C≥50 mg/dL) | (HDL-C<50 mg/dL) | (HDL-C≥50 mg/dL) | |||
| Age | 49.1 (3.4) | 48.9 (3.3) | 49.2 (3.5) | 56.7 (4.9) | 56.8 (5.0) | 56.7 (4.9) |
| Race, % White | 77.7 | 77.8 | 77.6 | 70.8 | 72.1 | 70.1 |
| Smoking status: | ||||||
| Current (%) | 21.1 | 30.1 | 16.6 | 25.3 | 31.4 | 21.9 |
| Former (%) | 34.4 | 18.6 | 27.2 | 21.7 | 18.7 | 23.4 |
| Never (%) | 54.6 | 51.3 | 56.2 | 53.0 | 49.9 | 54.8 |
| HDL-cholesterol mg/dL | 57.9 (16.3) | 41.2 (6.1) | 66.2 (13.2) | 57.8 (17.6) | 41.1 (6.2) | 67.1 (14.8) |
| High triglycerides (≥150 mg/dL, %) | 15.3 | 32.2 | 6.9 | 26.8 | 48.7 | 14.7 |
| Triglycerides (mg/dL) | 105.8 (71.4) | 142.0 (100.5) | 87.9 (40.6) | 130.8 (81.8) | 173.5 (105.6) | 107.2 (91.5) |
| Medication primarily lowering | 0.9 | 2.6 | 0.7 | 3.7 | 5.7 | 3.5 |
| cholesterol (%) | ||||||
| All cholesterol lowering medication (%) | 19.3 | 29.7 | 17.9 | 30.7 | 43.3 | 28.7 |
| Body mass index | 27.5 (6.3) | 30.0 (6.7) | 26.3 (5.7) | 27.9 (6.0) | 29.7 (5.9) | 26.9 (5.8) |
| Waist hip ratio | 0.88 (0.08) | 0.91 (0.08) | 0.86 (0.08) | 0.91 (0.08) | 0.94 (0.07) | 0.89 (0.08) |
| Diabetes, % | 7.0 | 12.7 | 4.1 | 12.4 | 21.1 | 7.5 |
| Education, (% less than high school) | 13.9 | 16.7 | 12.4 | 27.3 | 32.6 | 24.3 |
| Average age at menarche | 12.9 (1.8) | 12.8 (1.6) | 12.9 (2.0) | 12.9 (1.7) | 13.0 (1.7) | 12.9 (1.7) |
| Average age at menopause | - | - | - | 45.2 (1.7) | 45.1 (6.5) | 45.2 (6.4) |
| Average number of live births | 3.1 (1.8) | 3.2 (1.7) | 3.0 (1.8) | 3.4 (2.2) | 3.5 (2.2) | 3.3 (2.1) |
| Use of hormone replacement therapy | ||||||
| Current Estrogen (%) | 3.8 | 2.0 | 4.7 | 17.0 | 9.5 | 21.2 |
| Current Estrogen+Progesterone (%) | 10.8 | 5.9 | 13.3 | 3.6 | 1.8 | 4.7 |
| Never (%) | 74.3 | 79.9 | 71.5 | 59.1 | 67.9 | 54.2 |
| Former (%) | 8.3 | 9.5 | 7.6 | 17.0 | 17.7 | 16.6 |