Table 3.
Association of HDL-cholesterol and breast cancer incidence. ARIC study cohort, 1987–2000
| Total sample | Pre-menopause | Post-menopause | |||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of cases | P-years | HR*(95% CI) | No. of cases | P-years | HR*(95% CI) | No. of cases | P-years | HR*(95% CI) | |
| Quartile level of HDL-cholesterol (mg/dL) |
|||||||||
| <45 | 87 | 22 | 1.05 (0.73, 1.51) | 28 | 6,241 | 1.21 (0.64, 2.28) | 51 | 12,876 | 0.96 (0.58, 1.56) |
| 45–55 | 92 | 25 | 0.99 (0.72, 1.37) | 28 | 7,300 | 0.99 (0.56, 1.76) | 55 | 14,548 | 0.97 (0.62, 1.49) |
| 55–67 | 89 | 23 | 1.07 (0.79, 1.45) | 22 | 7,330 | 0.84 (0.47, 1.48) | 63 | 12,910 | 1.28 (0.86, 1.89) |
| >67 | 91 | 24 | 1.00 (referent) | 28 | 7,516 | 1.00 (referent) | 55 | 14,752 | 1.00 (referent) |
| HDL-cholesterol (mg/dL) |
|||||||||
| <50 | 131 | 33,146 | 1.08 (0.84, 1.40) | 45 | 9,295 | 1.67 (1.06, 2.63) | 75 | 19,225 | 0.93 (0.66, 1.30) |
| ≥50 (referent) | 228 | 62,029 | 1.00 | 61 | 19,092 | 1.00 | 149 | 35,861 | 1.00 |
| HDL-cholesterol (HR per one SD) |
1.02 (0.89, 1.16) | 1.02 (0.79, 1.30) | 1.06 (0.89, 1.25) | ||||||
| First 5 years of follow-up removed: | |||||||||
| HDL-cholesterol (mg/dL) |
|||||||||
| <50 | 92 | 32,810 | 1.34 (0.98, 1.82) | 36 | 9,245 | 2.25 (1.31, 3.86) | 48 | 18,976 | 1.07 (0.71, 1.63) |
| ≥50 (referent) | 141 | 61,613 | 1.00 | 36 | 19,012 | 1.00 | 95 | 35,567 | 1.00 |
| HDL-cholesterol (HR per one SD) |
0.93 (0.79, 1.11) | 0.92 (0.67, 1.26) | 0.92 (0.74, 1.13) | ||||||
HR: hazard ratio, 95% CI: 95 percent confidence interval, SD: standard deviation, P-years: person-years
*
Regression model adjusted for age, race_by_ARIC center, age at menarche, body mass index, cigarette smoking status, reproductive hormone use, age at menopause (total sample and post-menopausal women only).