Table 1. The frequency of alleles and genotypes of complement factor H rs1061170 SNP in Israeli NVAMD patients and unaffected controls.

Population	Age-related macular degeneration	Unaffected	p value	OR (95% CI)
By allele (T/C)
Entire population	237/243 (49.4%/50.6%)	152/84 (64.4%/35.6%)	0.0002	1.9 (1.3–2.6)
Ashkenazi Jews	147/161 (47.7%/52.3%)	87/47 (64.9%/35.1%)	0.0009	2 (1.3–3.1)
Sephardic Jews	74/72 (50.6%/49.4%)	51/29 (63.7%/36.3%)	0.07	1.7 (1–3)
By genotype
Entire Population
TT	55 (22.9%)	49 (41.5%)	0.00047
TC	127 (52.9%)	54 (45.8%)		2.1(1.3–3.4)
CC	58 (24.2%)	15 (12.7%)		3.4 (1.7–6.8)
Ashkenazi Jews
TT	33 (21.4%)	27 (40.3%)	0.003
TC	81 (52.6%)	33 (49.3%)		1.9 (1–3.8)
CC	40 (26%)	7 (10.4%)		13.9 (3.1–62.5)
Sephardic Jews
TT	18 (24.7%)	17 (42.5%)	0.19
TC	38 (52%)	17 (42.5%)		1.8 (0.7–1.9)
CC	17 (23.3%)	6 (15%)		2.8 (0.9–9.5)

Comparison of the frequency (%) of complement H rs1061170 variants between NVAMD patients and controls in the entire Israeli population and in the Ashkenazi and Sephardic subpopulations. Increased prevalence of the C variant was associated with the disease in the Ashkenazi subpopulation. CI- confidence interval, OR- odds ratio.