Table 2. Evaluation for association among clinical parameters in patients with NVAMD and complement factor H rs1061170 variants.
| Parameter |
rs1061170
genotype |
|||
|---|---|---|---|---|
| TT | CC | TC | P | |
| Gender (female/male) |
13/12 |
10/25 |
37/34 |
0.057 |
| Lesion type (classic/occult)* |
14/11 |
16/19 |
20/51 |
0.027 |
| Family History of AMD (yes/no) # |
2/23 |
6/21 |
11/47 |
0.353 |
| Age (mean ± SD, in years) |
78.4±9.63 |
78.5±7.44 |
78.68±7.89 |
0.989 |
| Initial VA (mean±SD, logMAR) |
1.1±0.82 |
1.15±0.91 |
1±0.71 |
0.659 |
| Lesion size (mean±SD, in µm) |
3965.7±1711.4 |
4074.4±1386.9 |
3580.1±1019.1 |
0.207 |
| Number of PDT sessions |
2.76±2.47 |
2.06±1.92 |
2.06±1.56 |
0.240 |
| Final VA (mean±SD, logMAR) | 1.53±0.98 | 1.53±0.95 | 1.35±0.84 | 0.547 |
Analysis for potential association among the wild type (T) and risk (C) alleles of the rs1061170 single nucleotide polymorphism in complement factor H and clinical parameters in patients with NVAMD is presented. There was no association between homozygosity for the risk allele and the factors which were evaluated. The asterisk represents that despite the presence of an association among heterozygosity and lesion type, there was no association between lesion type and rs1061170 when comparing lesion type in patients with TC and CC genotype combined with lesion type in patients with TT genotype, or when comparing lesion type between patients with the TT and CC genotypes. The following abbreviations and symbols are used: visual acuity (VA), photodynamic therapy (PDT); the sharp(hash mark) represents family history for age-related macular degeneration could not be reliably assessed for 21 patients.