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. 2008 Oct 16;3(10):e3408. doi: 10.1371/journal.pone.0003408

Figure 6. Possible model for PADI3 promoter regulation.

Figure 6

The binding of cJun and/or cFos dimers to the AP-1 sites of PIE is enhanced in calcium-stimulated keratinocytes and increases the rate of transcription of PADI3 (broken arrow). Transcription factors with functional association (cJun, cFos, NF-Y) are shown as open circles. Sp1/3 factors are denoted as grey circles. Transcription factors binding sites are indicated (capital letters). The arrows show the transcription orientation of the genes PADI1-2 (white boxes). TBP: TATA-box binding protein; pol II: RNA polymerase II.