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. 2008 Oct 13;3(10):e3378. doi: 10.1371/journal.pone.0003378

Figure 6. Schematic view of formaldehyde fixation stages.

Figure 6

On the top: formation of methylene glycol by the addition of water and formaldehyde. On the bottom: formaldehyde reacts with various parts of proteins molecules forming adducts. This reaction is followed by the formation of methylene bridges between closed proteins.