Figure 6. Drosophila AMP gene expression 24 hours post-infection.

Cecropins have a broad spectrum of activity against Gram-positive, Gram-negative, protozoan parasites, and fungi and are induced in the intestine during gut infections [38]. Real-time PCR was used to calculate the fold transcriptional activation above uninfected flies: (A) ditericin expression; (B) cecropin A1 expression; (C) drosomycin expression. Solid black circles indicate the response to PA01 alone; blue circles, examples of suppressed AMP expression during co-infection; red circles, AMP expression that can be explained by an additive effect; green circles, synergistic activation of AMP expression.