Table 1.
Neutralization of a highly pathogenic influenza virus (H5N1) with sera from immunized mice
| Vaccine | 50% neutralization titre (log2)1 | ||
|---|---|---|---|
| Exp. 1 | Exp. 2 | Exp. 3 | |
| Whole particle2 | 1·00 | 0·83 | 0·83 |
| Ether-split | <0 | <0 | <0 |
1
B6 mice were immunized as described in Figs 3 and 5. Sera were collected from three mice in each experiment. Diluted sera were incubated with a highly pathogenic influenza virus VN1194 (H5N1).
2
Average and standard deviation of 50% neutralization titres of sera from mice immunized with whole particle vaccines is 0·89 ± 0·098. P-value is less than 0·01 between whole particle and ether-split vaccines with Student's t-test when 50% neutralization titres of sera derived from mice immunized with ether-split vaccines are calculated as 0.