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Computer-aided lesion morphometry indicated more numerous granulomas (a) covering a larger total pulmonary surface area (b) in C57BL/6 mice (n = 6) vaccinated with Ag85B-ESAT-6 in DDA/MPL adjuvant relative to those vaccinated using Al(OH)3 adjuvant or unvaccinated at different time-points after challenge with 25 CFUs Mycobacterium tuberculosis Erdman by the aerosol route. *P < 0·05 and ***P < 0·001 compared to the corresponding values for naive mice.
