Table 3.

Consequences to variations in kinetic constants

Parameter	Frequencya		Amplitudea
	Fivefold decrease	Fivefold increase	Fivefold decrease	Fivefold increase
k1	1.5	−1.3	−4.5	3.8
k2	−1.3	1.3	−5.4	2.2
k3	1.3	−1.1	10.4	−3.9
k4	1.7	1.2	−5.0	5.3
k5	1.2	−1.1	−6.3	4.1
k6	1.3	−1.2	3.7	−5.6
k7	−1.5	1.5	1.8	−8.3
k8	−1.1	1.4	1.9	−1.5
k10	1.5	−1.4	1.5	−7.1
k12	−1.1	1.2	−14.7	−6.0
k13	1.2	−1.1	−10.0	4.5
k14	1.1	1.7	−1.2	−3.5

^aThe changes in either the frequency or amplitude of the oscillations in internal cAMP concentration as a consequence of a fivefold decrease or increase in each parameter are presented as the fold change relative to the standard simulation. The amplitude is defined as one-half of the difference in peak and trough values of internal cAMP concentration after three cycles.