Table 1. Demographic and clinical characteristics of the Spanish MS patients and healthy controls involved in the study.
| Characteristics | MS | HC |
| Original Spanish cohort * | ||
| n | 242 | 242 |
| Female/male (% women) | 161/81 (66.5%) | 158/84 (65.3%) |
| Age (years)a | 43.5 (11.0) | 43.9 (12.3) |
| RRMS/SPMS (% RRMS) | 184/58 (76.0%) | - |
| Spanish replication cohort ** | ||
| n | 100 | 100 |
| Female/male (% women) | 67/33 (67.0%) | 65/35 (65.0%) |
| Age (years)a | 41.8 (10.3) | 42.9 (12.6) |
| RRMS/SPMS (% RRMS) | 80/20 (80.0%) | - |
| US replication cohort ** | ||
| n | 275 | 275 |
| Female/male (% women) | 223/52 (81.0%) | 220/55 (80.0%) |
| Age (years)a | 37.6 (8.9) | 38.0 (9.5) |
| RRMS/SPMS (% RRMS) | 275/0 (100.0%) | - |
*Refers to patients used for DNA pooling. **Refers to patients used for individual validation. aData are expressed as mean (standard deviation, SD). RRMS: relapsing-remitting multiple sclerosis; SPMS: secondary progressive multiple sclerosis; HC: healthy controls.