Table 6. Linkage disequilibrium analysis between SNPs rs7326018 and rs1327328 and neighboring SNPs in chromosome 13.
SNP pairs | D′ | r2 | Chi2 | P value | |
rs7326018 | rs1330943 | 0.3836 | 0.0023 | 0.4106 | 0.5217 |
rs1327328 | 0.9539 | 0.9099 | 163.7904 | 1.89×10−15 | |
rs9588771 | 0.0000 | - | 0 | 1 | |
rs6492466 | 0.0563 | 0.0014 | 0.2467 | 0.6194 | |
rs9583760 | 0.2725 | 0.0282 | 5.0707 | 0.0243 | |
rs4284505 | 0.5002 | 0.1192 | 21.4486 | 3.63×10−6 | |
rs9589207 | 1.0000 | 0.0165 | 2.9644 | 0.0851 | |
rs1327328 | rs1330943 | 0.3836 | 0.0023 | 0.4106 | 0.5217 |
rs9588771 | 0.0000 | - | 0 | 1 | |
rs6492466 | 0.0563 | 0.0014 | 0.2467 | 0.6194 | |
rs9583760 | 0.2725 | 0.0282 | 5.0707 | 0.0243 | |
rs4284505 | 0.5668 | 0.153 | 27.5447 | 1.54×10−7 | |
rs9589207 | 1.0000 | 0.0165 | 2.9644 | 0.0851 |
SNPs rs1330943 and rs9588771 are located in ENSG00000165618 and ENSG00000184837 genes respectively; rs6492466 and rs9583760 are located within LOC121727; rs4284505 is located close to a cluster of microRNAs and rs9589207 within the hsa-mir-92a-1 microRNA. Linkage disequilibrium measures are highly significant between SNPs rs1327328 and rs7326018 and SNP rs4284505, and marginally significant with SNP rs9583760 (p values are represented in bold).