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. 2008 Sep 12;36(18):5832–5844. doi: 10.1093/nar/gkn549

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Evolution of TFIIIA sequence throughout eukaryotes. The nine filled rectangles in the top sequence (X. laevis) symbolize the nine zinc fingers. The last zinc finger in S. cerevisiae TFIIIA is also traditionally numbered nine because this sequence was obtained prior to that of S. pombe that exhibits 10 zinc fingers. Multiple sequences alignment (not shown) confirm that finger 9 of S. pombe sequence corresponds to finger 9 of X. laevis sequence and that fingers 9 of S. cerevisiae and Y. lipolytica correspond to finger 10 of S. pombe. In TFIIIA from Y. lipolytica, an extra 10th zinc is present between finger 9 and the last block of homology common to all hemiascomytes (small dark vertical rectangle). See also alignment in Supplementary Data 5.