Table 2.

Predicted binding sites for NRs on the miR-433 gene promoter

TF name	Optimized matrix threshold	Strand	Core similarity	Matrix similarity	Sequence (capitals: core sequence)
Farnesoid X - activated receptor (RXR/FXR dimer), IR1 sites	0.8	(+)	1	0.884	AGGTcagtgtccc
Farnesoid X - activated receptor (RXR/FXR dimer), IR1 sites	0.8	(+)	0.875	0.8	GGGTcactggcat
PPAR/RXR heterodimers, DR1 sites	0.76	(−)	0.753	0.764	cccagccagggaacAGGCaaggc

The NR-binding sites on the promoter regions of the two primary transcripts were predicted using software MatInspector. The predicted hits were mainly filtered out based on the criteria of Core Similarity 1 and a Matrix similarity of more than 0.8.