Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Sep 6;36(18):5750–5762. doi: 10.1093/nar/gkn553

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 3. — Frequency of complete V_H-to-D_H-to-J_H and direct V_H-to-D_H rearrangements in cR2 and WT mice. (A) Diagram of a portion of the mouse IgH locus in its germline configuration (upper; only a subset of the total number of D segments bounded by RSS-12 are shown) as well as complete VDJ and direct VD rearrangements (VD-del and VD-inv, deletion and inversion) utilizing V_H81x and DFL16.1. Real-time qPCR primers are shown as horizontal arrows and the probe (line bounded by circles). (B) DNA purified from the indicated tissues was analyzed for complete VDJ (upper) or direct VD joints (middle and lower; deletion or inversion). Hybrid joints (not illustrated) were excluded by placing the D segment primer just within that coding segment. Four animals from each of the three possible genotypes were examined and the mean values (bars) with SEs (whiskers) are shown.