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. 2008 Oct 14;6(10):1–18. doi: 10.1371/journal.pbio.0060249

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© 2008 Ruan et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A–D) Representative PER2::LUC bioluminescence traces recorded from cultured mPer2^Luc retinal explants that received different doses of GABA treatment. Bars indicate the duration of GABA treatment.

(E) Dose-dependent inhibitory action of GABA on the amplitude of retinal PER2::LUC rhythms. The ratio of the peak-to-trough amplitude of the fourth cycle to that of the second cycle (A₄/A₂) was plotted as a function of the external GABA concentration. Data are represented as mean ± SEM (n = at least 3 explants per point).