Table 1. Cytokine responses to mycobacterial antigens in BCG vaccinated infants.
| Cytokine | Antigena | Numbers availableb | Non-responders (%)c | Geometric mean (pg/ml, 95% CI) |
| IFN-γ | PHA | 232 | 42 (18) | 58.37 (42.59–80.02) |
| N = 236 | PPD | 236 | 5 (2) | 845.39 (692.67–1031.79) |
| Ag85 | 228 | 26 (11) | 76.23 (56.14–103.52) | |
| STCF | 236 | 27 (11) | 99.15 (73.21–134.28) | |
| KMTB | 236 | 2 (1) | 1574.70 (1278.33–1939.78) | |
| IL-13 | PHA | 200 | 55 (28) | 11.79 (8.99–15.47) |
| N = 200 | PPD | 200 | 45 (23) | 8.02 (6.46–9.95) |
| Ag85 | 200 | 138 (69) | 1.61 (1.42–1.82) | |
| STCF | 200 | 87 (44) | 3.64 (2.99–4.43) | |
| KMTB | 200 | 61 (31) | 6.45 (5.20–8.01) | |
| IL-5 | PHA | 153 | 110 (72) | 1.97 (1.60–2.43) |
| N = 155 | PPD | 154 | 64 (42) | 7.83 (5.68–10.80) |
| Ag85 | 154 | 115 (75) | 2.18 (1.72–2.78) | |
| STCF | 155 | 93 (60) | 3.89 (2.90–5.21) | |
| KMTB | 153 | 76 (50) | 5.57 (4.08–7.61) |
a
Concentration 10 µg/ml.
b
Discrepancies between number available and total number in study are due to technical failure for a few samples in the IFN-γ and IL-5 groups.
c
non-responders defined as cytokine level of 0 or less after background subtracted; percentages rounded up to nearest integer.
IFN-γ: interferon-gamma; IL-13: interleukin-13; IL-5: interleukin-5; PHA: phytohaemagglutinin; PPD: purified protein derivative; Ag85: antigen 85; STCF: short term culture filtrate; KMTB: killed Mycobacterium tuberculosis.