Table 1. Identification of SOD1-interacting proteins in spinal cord of DF, WF and NTG mice aged 145 days.
| DF | WF | NTG | ||||||||||
| Protein | Abbreviation | Accession no. | Probability score | No. of peptide | Protein | Accession no. | Probability score | No. of peptide | Protein | Accession no. | Probability score | No. of peptide |
| HSPs and protein degradation | ||||||||||||
| heat shock cognate 70 | Hsc70, HspA8 | 13242237 | 170.22 | 20 | heat shock cognate 70 | 13242237 | 30.17 | 3 | ||||
| heat shock protein 70-2 | Hsp70-2, HspA2 | 123621 | 80.25 | 10 | heat shock protein 70-2 | 123621 | 30.16 | 3 | ||||
| heat shock 70 protein 1-like | Hapa1L | 56757584 | 40.25 | 4 | ||||||||
| heat shock protein 9A | HspA9A | 6754256 | 30.16 | 3 | ||||||||
| ubiquitin carboxy-terminal hydrolase L1 | UCHL1 | 61098212 | 20.24 | 3 | ||||||||
| ATPases | ||||||||||||
| Na/K ATPase α 2 subunit | ATP1A2 | 30409956 | 120.19 | 12 | ||||||||
| Na/K ATPase α 3 subunit | ATP1A3 | 27552786 | 100.20 | 10 | ||||||||
| Na/K ATPase α 1 subunit | ATP1A1 | 21450277 | 40.18 | 4 | ||||||||
| ATP synthase β subunit | ATP5B | 31980648 | 80.25 | 9 | ||||||||
| ATP synthase α subunit | ATP5A | 6680748 | 50.20 | 5 | ||||||||
| ATP synthase γ subunit | ATP5C | 11602916 | 30.17 | 3 | ||||||||
| Glycogenolysis, glycolysis, and TCA cycle | ||||||||||||
| α (non-neuron) enolase* | ENO1 | 12963491 | 70.25 | 7 | pyruvate kinase | 2506796 | 50.22 | 5 | ||||
| lactate dehydrogenase | LDH | 6678674 | 60.22 | 6 | ||||||||
| brain glycogen phosphorylase* | PYGB | 24418919 | 30.25 | 3 | ||||||||
| phosphofructokinase 1 | PFKA, PFKM | 13638207 | 30.20 | 3 | ||||||||
| malate dehydrogenase 1 | MDH1 | 31982178 | 30.17 | 3 | ||||||||
| aconitase 2 | ACO2 | 18079339 | 30.16 | 3 | ||||||||
| glyceraldehyde-3-phosphate dehydrogenase | GAPDH | 6679937 | 20.33 | 3 | ||||||||
| Cytoskeleton and structure | ||||||||||||
| α tubulin | TUBA | 34740335 | 140.22 | 14 | keratin | 6678643 | 30.21 | 3 | keratin | 627899 | 50.21 | 6 |
| β tubulin | TUBB | 5174735 | 120.25 | 13 | β actin | 4501885 | 30.21 | 3 | ||||
| β actin | ACTB | 49868 | 60.20 | 6 | ||||||||
| cofilin 1 | CFL1 | 6680924 | 50.26 | 5 | ||||||||
| microtubule-associated protein 2 | MAP2 | 126741 | 50.23 | 5 | ||||||||
| myelin basic protein* | MBP | 6754658 | 30.16 | 3 | ||||||||
| Membrane and protein trafficking | ||||||||||||
| syntaxin binding protein 1 | STXBP1 | 21594764 | 40.19 | 5 | ||||||||
| clathrin heavy chain | CLTC | 51491845 | 40.20 | 4 | ||||||||
| Protein biosynthesis | ||||||||||||
| eukaryotic translation elongation factor 1 | eEF1A | 51873060 | 40.17 | 4 | ||||||||
| Others | ||||||||||||
| 2′,3′-cyclic-nucleotide 3′-phosphodiesterase I* | CNP | 2160434 | 80.19 | 8 | mouse Cu/Zn superoxide dismutase | 45597447 | 20.22 | 3 | ||||
| dihydropyrimidinase-like 2 | DPYSL2 | 40254595 | 50.20 | 5 | ||||||||
| latexin | LXN | 31980632 | 40.25 | 5 | ||||||||
| solute carrier family 25, member 4 | SLC25A4 | 82917335 | 40.22 | 4 | ||||||||
| solute carrier family 25, member 5 | SLC25A5 | 22094075 | 30.22 | 3 | ||||||||
| solute carrier family 25, member 12 | SLC25A12 | 27369581 | 30.21 | 4 | ||||||||
| glutamate oxaloacetate transaminase 2 | GOT2 | 6754036 | 40.21 | 4 | ||||||||
*
Proteins expressed in non-neural cells.