Table I.
Association of mtDNA markers with multiple sclerosis (MS) and systemic lupus erythematosus SLE. All p<0.05 are indicated. After correction for multiple testing, significant associations are observed for the mtDNA nt9055 variant of the ATP6 gene (in haplogroup K) in both MS and SLE, and for the nt4719 variant of the ND2 gene (in haplogroup T) in MS.
Gene | ND2 | ATP6 | CYTB | |
---|---|---|---|---|
Marker | Mt4917 | mt9055 | mt14798 | |
MS-control | χ2 | 7.56 | 34.7 | 4.76 |
p | 0.006 | <0.0001 | 0.029 | |
Associated variant | G(A/G) | A(G/A) | C(T/C) | |
Freq. in controls/MS | 0.876/0.928 | 0.024/0.133 | 0.151/0.205 | |
SLE-control | χ2 | 11.8 | 7.45 | 0.31 |
p | 0.033 | 0.006 | 0.576 | |
Associated | * | G(A/G) | A(G/A) | C(T/C) |
Freq. in controls/SLE | * | 0.876/0.970 | 0.025/0.089 | 0.849/0.872 |