Table 1.

Comparison of the genomes of a central African strain of monkeypox virus (Zaire-1979) and a west African strain of monkeypox (USA-2003)

Gene Ortholog Name	Predicted Protein Function	Present in MPV-ZAR_1979_005	Present in MPV-USA_2003_039
COP-A49R 162 aa	Unknown	-	Fragment 69 aa: Central
COP-A52R 190 aa	Bifunctional Toll-IL-1-receptor protein	-	Fragment 63 aa: N-term
COP-A55R 564 aa	Kelch protein	Fragment 82 aa: C-term	Fragment 112 aa: Central
COP-B17L 340 aa	Unknown	Fragment 55 aa: Central 78 aa: C-term	Fragment 55 aa: Central
COP-C2L 512 aa	Kelch protein	Fragment 107 aa: N-term 176 aa: Central 105 aa: C-term	Fragment 112 aa: N-term
COP-C3L 263 aa	Inhibitor of complement enzymes	Truncated 216 aa: N-term/Central	-
COP-E5R 331 aa	Unknown	Fragment 67 aa: N-term 64 aa: C-term	Fragment 62 aa: N-term 69 aa: N-term
BR-19 796 aa	Unknown	Fragment 55 aa: N-term 56 aa: N-term 73 aa: C-term	-
BR-20 170 aa	Unknown	Fragment 64 aa: C-term	-
BR-158 1284 aa	CPV A-type inclusion protein	Fragment 696 aa: N-term/Central 54 aa: C-term 67 aa: C-term 75 aa: C-term	Fragment 696 aa: N-term/Central 110 aa: Central 82 aa: C-term 100 aa: C-term
BR-203 225 aa	Virulence protein	+ 221 aa	Fragment 51 aa: N-term
BR-209 326 aa	IL-1β binding protein	Fragment 210 aa: N-term/Central 126 aa: C-term	Fragment 163 aa: Central 132 aa: C-term

Abbreviations: aa: amino acids; BR: cowpox virus strain Brighton Red; C-term: C-terminal fragment; COP: vaccinia virus, strain Copenhagen; CPV: cowpox virus; IL: Interleukin; MPV-Zar_1979_005: central African strain of monkeypox virus; MPV-USA_2003_039: west African strain of monkeypox virus; N-term: N-terminal fragment.