Figure 1.

Tumour growth after the treatment with EGCG and tamoxifen. Female athymic nude mice were implanted with MDA-MB-231 cells (2 × 10⁶) and treated for 70 days. (A) Tumour volume during the treatment with vehicle (5 ml kg⁻¹), EGCG (25 mg kg⁻¹, i.p.), tamoxifen (50 μg kg⁻¹, p.o.), or EGCG+tamoxifen. (B) The tumour volume during treatment with vehicle (5 ml kg⁻¹), EGCG (25 mg kg⁻¹, i.p.), tamoxifen (75 μg kg⁻¹, p.o.), or EGCG+tamoxifen. (C) Tumour weight after 70 days of treatment with EGCG (25 mg kg⁻¹, i.p.) and tamoxifen (75 μg kg⁻¹, p.o.). Symbols and bars represent the mean±s.e.m. from 10 mice per group. ^*Combination treatment significantly different from vehicle control (P<0.05). ^**Combination treatment significantly different from all other groups (P<0.05).