Table 1. Univariate logistic regression for chemotherapy response (good vs poor).
| Clinical variable | N (%) | OR | CI | P | |
|---|---|---|---|---|---|
| Age (years) | |||||
| ⩽50 | 52 (54%) | 1 | |||
| >50 | 45 (46%) | 1.09 | (0.47, 2.51) | 0.842 | |
| Stage | |||||
| I or II | 19 (19%) | 1 | |||
| III or IV | 79 (81%) | 0.89 | (0.32, 2.53) | 0.833 | |
|
Poor
|
Good
|
||||
| Markers | N | Mean (s.d.)a | N | Mean (s.d.) | P ** |
| CA125 | |||||
| Baseline (c0) | 37 | 5.488 (2.227) | 57 | 4.401 (1.854) | 0.023 |
| rc1=log(c0/c1) | 34 | 0.121 (1.069) | 53 | 0.753 (1.105) | 0.003 |
| rc2=log(c1/c2) | 20 | 0.339 (0.473) | 34 | 0.587 (1.191) | 0.986 |
| rc1/rc2 | 20 | 0.181 (1.215) | 33 | 0.223 (1.338) | 0.279 |
| KLK5 | |||||
| Baseline (c0) | 37 | −1.776 (1.629) | 58 | −1.657 (1.03) | 0.466 |
| rc1=log(c0/c1) | 35 | −0.141 (1.016) | 54 | 0.372 (0.903) | 0.016 |
| rc2=log(c1/c2) | 22 | 0.111 (0.482) | 34 | 0.217 (0.584) | 0.860 |
| rc1/rc2 | 22 | −0.141 (1.216) | 34 | 0.134 (1.149) | 0.140 |
| KLK6 | |||||
| Baseline (c0) | 37 | 3.077 (0.808) | 58 | 2.562 (0.743) | 0.002 |
| rc1=log(c0/c1) | 35 | 0.175 (0.668) | 53 | 0.084 (0.645) | 0.932 |
| rc2=log(c1/c2) | 22 | 0.036 (0.568) | 34 | 0.082 (0.466) | 0.827 |
| rc1/rc2 | 22 | 0.286 (1.191) | 34 | 0.003 (0.927) | 0.627 |
| KLK7 | |||||
| Baseline (c0) | 37 | 1.283 (0.501) | 58 | 1.071 (0.579) | 0.0747 |
| rc1=log(c0/c1) | 35 | 0.013 (0.374) | 53 | 0.012 (0.537) | 0.956 |
| rc2=log(c1/c2) | 22 | 0.016 (0.291) | 34 | 0.078 (0.319) | 0.568 |
| rc1/rc2 | 22 | 0.01 (0.581) | 34 | −0.16 (0.557) | 0.450 |
| KLK8 | |||||
| Baseline (c0) | 37 | 2.54 (0.653) | 58 | 2.246 (0.569) | 0.017 |
| rc1=log(c0/c1) | 35 | 0.062 (0.466) | 53 | 0.019 (0.511) | 0.673 |
| rc2=log(c1/c2) | 22 | −0.013 (0.405) | 34 | 0.114 (0.364) | 0.302 |
| rc1/rc2 | 22 | 0.07 (0.737) | 34 | −0.15 (0.717) | 0.227 |
| KLK10 | |||||
| Baseline (c0) | 37 | 1.463 (0.864) | 58 | 1.022 (0.947) | 0.013 |
| rc1=log(c0/c1) | 35 | 0.126 (0.511) | 53 | 0.198 (0.74) | 0.805 |
| rc2=log(c1/c2) | 22 | 0.073 (0.218) | 34 | 0.076 (0.351) | 0.481 |
| rc1/rc2 | 22 | 0.073 (0.709) | 34 | 0.108 (0.7) | 0.663 |
| KLK11 | |||||
| Baseline (c0) | 36 | 0.052 (0.774) | 57 | −0.199 (0.737) | 0.196 |
| rc1=log(c0/c1) | 34 | 0.001 (0.632) | 53 | 0.192 (0.677) | 0.058 |
| rc2=log(c1/c2) | 22 | 0.129 (0.358) | 34 | 0.066 (0.306) | 0.574 |
| rc1/rc2 | 21 | 0.03 (0.901) | 34 | 0.176 (0.527) | 0.161 |
| B7-H4 | |||||
| Baseline (c0) | 35 | 1.216 (1.006) | 52 | 0.719 (0.976) | 0.009 |
| Reg-IV | |||||
| Baseline (c0) | 34 | −0.246 (0.517) | 49 | −0.518 (0.521) | 0.027 |
| Spondin-2 | |||||
| Baseline (c0) | 34 | 4.398 (0.551) | 49 | 4.209 (0.542) | 0.101 |
CI=confidence interval; OR=odds ratio.
a
Logarithmically transformed values.
**
Wilcoxon Rank Sum test.