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. 2008 Sep 16;99(7):1074–1082. doi: 10.1038/sj.bjc.6604676

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Copyright © 2008 Cancer Research UK

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In vitro anti-tumour activity of dasatinib. BxPC-3, PANC-1 and MIA PaCa-2 cells were pretreated with 0, 25, 50, 100 and 200 nM dasatinib for 24 or 48 h. (A) Effects of 48 h treatment with dasatinib on the in vitro growth of BxPC-3, PANC-1 and MIA PaCa-2 cells at the indicated concentrations were measured by MTS assay. ^*Statistically significant from control (P<0.05). (B) Single parameter DNA histograms showed the cell cycle effects of 24 h treatment with dasatinib at the indicated concentrations. Percent cells in G1-S-G2/M phase are given. CV, coefficient of variation.