Table 2.
Egg burden (mean ± SE) in immunized and control water buffaloes in trials 1 and 2, and percent reduction in egg burden in immunized animals compared with their corresponding control group (pVAX) in each trial.
| Group | Eggs per gram liver |
Eggs per gram feces |
Hatched miracidia per gram feces |
|||
|---|---|---|---|---|---|---|
| Mean ± SE | Vaccine Efficacy (%)a, (95% CI) | Mean ± SE | Vaccine Efficacy (%)a, (95% CI) | Mean ± SE | Vaccine Efficacy (%)a, (95% CI) | |
| Trial 1 | ||||||
| pVAX | 459.0 ± 25.6 | --- | 23.8 ± 1.7 | --- | 18.4 ± 1.6 | --- |
| (n = 15) | ||||||
| SjCTPI | 266.4 ± 24.2 | 42.0% | 14.7 ± 1.3 | 38.3% | 12.3 ± 1.1 | 33.2% |
| (n = 13) | (30.4%, 51.6%) | (24.6%, 49.4%) | (16.2%, 46.7%)b | |||
| SjCTPI-Hsp70 | 177.0 ± 11.5 | 61.5% | 11.4 ± 0.7 | 52.1% | 8.8 ± 0.7 | 52.1% |
| (n = 15) | (54%, 67.7%) | (41.3%, 60.9%) | (39.4%, 62.2%) | |||
| Trial 2 | ||||||
| pVAX | 500.1 ± 26.5 | --- | 32.5 ± 2.1 | --- | 26.5 ± 1.0 | --- |
| (n = 13) | ||||||
| SjC23 | 285.7 ± 21.7 | 42.9% | 19.5 ± 0.9 | 40.2% | 13.9 ± 0.6 | 47.4% |
| (n = 15) | (32.3%, 51.8%) | (30.0%, 48.9%) | (37.1%, 56.0%) | |||
| SjC23-Hsp70 | 230.6 ± 13.6 | 53.9% | 16.9 ± 0.8 | 48.0% | 12.7 ± 0.7 | 52.0% |
| (n = 15) | (45.6%, 60.9%) | (39.1%, 55.5%) | (42.8%, 59.7%) | |||
a
Percent reduction in egg burdens were significant at p<0.0001;
b
significant at p< 0.001; CI: 95% confidence intervals. n represents the number of animals in each group at the time of perfusion.