Fig. 4.

Experimental design for TRIP-mediated ablation of proliferating cells. The mouse strain carrying the chromosome 2 with loxP sites in inverse orientation (triangles, invloxP allele) is crossed with a mouse expressing a Cre transgene under the control of a tissue-specific promoter. In the resulting progeny, ablation of proliferating cells due to the recombination between the inverted loxP sites occurs specifically in Cre-expressing tissue (orange circle) of double heterozygous specimens (invloxP/+; Cre).