Table 4.

Electron density within cavities in T4 lysozyme L99A/M102L

Cavity	Volume of cavity, Å3	Resolution of density map*, Å	Experimental electron density within cavity				Experimental integrated density within cavity (electrons)	Inferred water molecules in cavity	Model integrated density within cavity (electrons)†
			Min, e/Å3	Max, e/Å3	Mean, e/Å3	rmsd, e/Å3
1	45.2	1.25	−0.52	4.37	0.36	0.71	16.1	2	16.8 (2)
		1.50	−0.61	3.75	0.36	0.66	16.4
2	16.9	1.25	−0.54	3.85	0.46	0.73	7.7	1	8.0 (1)
		1.50	−0.40	3.37	0.48	0.69	8.0
3	21.4	1.25	−0.94	0.91	−0.04	0.35	−0.8	0	0.7 (0)
		1.50	−0.77	0.78	−0.01	0.32	−0.3
4	133.5	1.25	−0.71	1.05	0.12	0.28	16.2	1.5	3.7 (0)
		1.50	−0.65	0.93	0.13	0.27	17.6

*Phasing at 1.50-Å resolution was performed independently from that at 1.25 Å.

^†The model calculations were to 1.25-Å resolution based on the structure factors and phases calculated from the refined structure of L99A/M102L. The value in parentheses is the number of water molecules in the cavity included in the model calculation.