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Repeated infusions of ECDI-treated donor splenocytes induce significant graft protection in allogeneic islet cell transplantation. (A) Time line of the treatment protocols. (B) Graft survival. Day 0 indicates the day of islet transplantation. ECDI-treated BALB/c cells vs. control, P = 0.0036; ECDI-treated SJL cells vs. control, P = 0.2178; untreated BALB/c cells vs. control, P < 0.0001.
