Fig. 4.

Diminished alloantigen-specific T-cell and antibody responses are associated with protection of allogeneic islet grafts. (A) DTH responses. P = 0.0018, rejecting vs. tolerized recipients. (B) Specific anti-donor antibodies were measured for IgG1, IgG2a, IgG2b, and IgG3. The top two rows of histograms are results from two control (rejected) recipients. The bottom two rows of histograms are results from two long-term tolerized recipients. Data are representative of two individual experiments. Shaded histogram indicates syngeneic cells. (C) Mixed lymphocyte reaction and IFN-γ production. Thy1.2⁺ T cells from the spleens and peripheral lymph nodes from control and tolerized recipients were used. P values are indicated in the graphs. Data are representative of three separate experiments.