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. 2008 Sep 15;105(38):14656–14661. doi: 10.1073/pnas.0805705105

Fig. 4.

Fig. 4.

Effect of enhancing neural excitability on the correlation between pr and postsynaptic GluR2 fluorescence level. (A and B) Summary of GluR2 level versus pr relationship from 14–15 DIV neurons (A, n = 61 boutons, five coverslips) and 20–22 DIV neurons (B, n = 54 boutons, five coverslips) treated with 5 mM KCl and 10 μM bicuculline for 2 days (filled circles). Each point represents an average from five to six boutons. Dotted lines are linear regression fits. Data from the control experiment is also shown (open circles). Correlation coefficient (r) and P value (p) by Spearman rank correlation test are indicated. At both culture ages, treatment with KCl and bicuculline significantly increases the correlation between pr and GluR2 level. (C and D) Cumulative distribution plots of pr at 14–15 DIV (C) and 20–22 DIV (D). (E and F) Cumulative distribution plots of GluR2 level at 14–15 DIV (E) and 20–22 DIV (F). Treatment with KCl and bicuculline decreased GluR2 level. K-S test, P = 0. 0136 (14–15 DIV), P = 0.0002 (20–22 DIV).