Fig. 1.
Voluntary running increases the stem cell pool after irradiation. (A) Confocal microscopic analysis [GFAP-positive cells (red), Sox-2-positive cells (green)] revealed a significant decrease in the number of proliferative precursor cells in the DG of irradiated nonrunning compared with sham-irradiated nonrunning mice. (Scale bar, 10 μm.) (B) After voluntary running, there was a significant increase in the number of double-positive cells compared with irradiated nonrunning mice. Group means ± SEM are shown. *, P < 0.05; **, P < 0.01.