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. 2008 Sep 2;105(38):14632–14637. doi: 10.1073/pnas.0711128105

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© 2008 by The National Academy of Sciences of the USA

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Fig. 2. — Voluntary running increases neurogenesis after irradiation. (A and D–G) Confocal microscopic analysis [BrdU-positive cells (red), NeuN-positive cells (green)] revealed a percentage increase in the number of newborn neurons in running and irradiated running mice compared with sham-irradiated nonrunning and irradiated nonrunning mice. (Scale bar, 20 μm.) (B) The total number of newly generated neurons in the GCL increased after voluntary running compared with control and irradiated animals. (C) Measurement of the GCL showed a significant decrease in volume in the irradiated animals compared with sham-irradiated nonrunning and sham-irradiated running animals. Group means ± SEM are shown. *, P < 0.05; **, P < 0.01.