. 2008 Oct;180(2):845–856. doi: 10.1534/genetics.108.092494

TABLE 1.

F52Y secondary mutations

Mutant	Codon change	Location	Other nearby mutations
T51A	ACC to GCC	AT H1-S2 loop	F52I, F52L, F52Y: Tg dinitroaniline^R (Morrissette et al. 2004)
V181I	GTT to ATT	AT β-5 to α-5 loop	S180P, A180T: At twisting (monomer interface) (Ishida et al. 2007a)
A273V	GCG to GTG	AT M loop	I275T: Tg dinitroaniline^R (Morrissette et al. 2004)
K280N	AAG to AAC	AT M loop	K279A-K281A: Sc benomyl^ss (Richards et al. 2000), A281T: At twisting (Ishida et al. 2007a)
N293D	AAC to GAC	AT α-helix 9	A295V: Tg dinitroaniline^R (Morrissette et al. 2004)
A295G	GCT to GGT	AT α-helix 9	A295V: Tg dinitroaniline^R (Morrissette et al. 2004)
S300T	AGC to ACC	AT α-9 to β-8 loop	S300T: Ant. fish cold^R (Detrich et al. 2000), M301T: Tg dinitroaniline^R (Morrissette et al. 2004)
M313T	ATG to ACG	AT β-sheet 8	D310A-K312A: Sc benomyl^ss (Richards et al. 2000)
P360A	CCC to GCC	AT near insert	G354E: Ce mec-12 (Fukushige et al. 1999)
T361P	ACT to CCT	AT insert
P364A	CCT to GCT	AT insert
P364R	CCT to CGT	AT insert	Also suppresses G142S
G366R	GGT to CGT	AT insert
D367V	GAC to GTC	AT insert
L368F	TTG to TTC	AT insert
R373C	CGC to TGC	AT β-sheet 10	D373A-R374A: Sc benomyl^ss (Richards et al. 2000)
G34S	GGT to AGT	BT H1-S2 loop	G34S: Ce mec-7 (Savage et al. 1989)
G82D	GGC to GAC	BT α-2 to β-3 loop	F85L: Tg suppressor of G142S
P261S	CCT to TCT	BT α-8 to β-7 loop	F261V: Hs paclitaxel^R (Monzo et al. 1999)
G269V	GGG to GTG	BT β-sheet 7	G269D: Ce mec-7 (Savage et al. 1989)
L273V	CTC to GTC	BT M loop	T274I: Hs epothilone/taxane^R (Giannakakou et al. 2000)
H396Q	CAC to CAG	BT α-helix 11	A393T: Ce mec-7 (Savage et al. 1989); A394T: At twisting (Ishida et al. 2007a)

At, Arabidopsis thaliana; Ant. fish, Antarctic fish; Ce, Caenorhabditis elegans; Hs, Homo sapiens; Sc, Saccharomyces cerevisiae; Tg, Toxoplasma gondii; ^R, resistant; ^ss, supersensitive.