Skip to main content
. 2008 Sep 11;27(19):2471–2483. doi: 10.1038/emboj.2008.182

Figure 5.

Figure 5

Model of dynein regulation by LIS1 and NDEL1. Schematic presentation of the dynein regulation by LIS1 and NDEL1. LIS1 fixes dynein on tMT (freighter tubulins). This complex is transported to the plus end of cytoskeletal MTs in a kinesin-dependent manner. In contrast, NDEL1 activates the dynein–LIS1 complex, and enables LIS1 protein to accumulate around the centrosome by dynein-dependent transport. Presumably, the generation of the dynein–LIS1–tMT freighter complex requires high concentrations of LIS1 protein around the centrosome.