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ArmR can bind MexR in two mutually exclusive orientations. Regardless of the orientation, the four hydrophobic pockets of MexRLL (dashed outlines labeled I, II, I' and II') are filled by aromatic ArmRC residues, revealing physicochemical symmetry within the ArmRC C terminus. MexRLL is shown as a cross-sectioned hydrophobic surface where green represents relative hydrophobicity.
