Fig. 3.
Location of positively selected and functionally divergent sites in exon 1. The black bar represents exon 1 of HoxA-11, red marks indicate the relative locations of sites that were substituted in the stem-lineage of eutherians. The two sequence logos show site variation within eutherians (Top) and the noneutherians (Bottom). The inferred amino acids at these sites is shown for the reconstructed therian ancestor (Middle). Amino acids are color coded by physicochemical property. +, site identified under positive selection; θI, type I site; θII, type II site. The rate of evolution of these sites is shown for eutherians and noneutherians.