Table 1.
Biochemical studies indicating HPP
| Test | Patient (sib no. 1) | Father | Mother | Sister (sib no. 2) | Brother (sib no. 3) | Normal rangea | ||
|---|---|---|---|---|---|---|---|---|
| Age (yr)b | 3 | 29 | 28 | 4 | 2.5 | 6 | Pediatric | Adult |
| Serum | ||||||||
| ALP (IU/liter) | 47 | 55 | 32 | 308 | 36 | 63 | 133–347 | 30–114 |
| BALP (IU/liter)c | 29 | 21 | 11 | 144 | 30 | 36 | 47–181 | 3–38 |
| Plasma | ||||||||
| PLP (nmol/liter) | 3505 | 191 | 258 | 117 | 1332 | 4034 | 5–107 | 5–107 |
a
Normal ranges (±2 sd mean) were constructed from data from fasting blood specimens obtained from 20 children ages 4.6–12.9 yr with ad libitum diets and assayed at Shriners Hospital for Children, in 1997. The range for plasma PLP concentration is appropriate for both children and adults (18).
b
Age when samples for biochemical studies were obtained.
c
Metra Biosystems, Inc., Mountain View, CA.