Figure 3.
Effects of acute (10 mg kg−1) or subchronic treatment with SB-271046 (10 mg kg−1, twice daily, 7 days), alone or in combination with galanthamine (2.5 mg kg−1) on learning impairments induced by MK-801 (0.2 mg kg−1) (upper panel) and mean latency on days 2 and 3 of the Morris water maze (lower panel). C, control; MK, MK-801; SBac, acute SB-271046; SBc, subchronic SB-271046; G, galanthamine. Data represented are mean±s.e.mean of latency to find the platform (s) of 12 rats on treatment. Statistical analysis of data on upper panel, repeated measures followed by analysis of simple effects (see text for details). *P<0.05 vs control; †P<0.05 vs MK-801.