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. 2008 Jun 30;155(3):335–342. doi: 10.1038/bjp.2008.269

Figure 1.

Figure 1

Effect of isosorbide mononitrate (ISMN) treatment on soluble guanylyl cyclase (sGC) in rabbits. Protein expression of (a) sGC α1 subunit (P=0.2790) and (b) sGC β1 subunit in aortae of ISMN-treated rabbits measured by western blot densitometry. Neither the low-dose (ISMN-2) nor the high-dose (ISMN-200, each n=10, P=0.6900, analysis of variance (ANOVA)) group showed a significant change in protein expression. (c) Activity of sGC protein measured in pmol cGMP per mg protein per min in ISMN-treated rabbits. There was no significant difference among all three groups (n=6–7, P=0.0775, ANOVA). Results shown represent mean±s.e.m.