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. 2008 Oct 15;105(43):16809–16813. doi: 10.1073/pnas.0805677105

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© 2008 by The National Academy of Sciences of the USA

Freely available online through the PNAS open access option.

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Fig. 4. — Bioevaluation studies with BI-78D3. (A) TR-FRET analysis of c-Jun phosphorylation upon TNF-alpha stimulation of HeLa cells in the presence of increasing BI-78D3. (B) BI-78D3 effect on serum alanine-aminotransferase levels after 7.5 h of exposure to ConA compared with DMSO control. Results shown are averages ± SD (n = 7). (C) Effect of BI-78D3 (25 mg/kg) on insulin resistance in 11-week-old BKS.Cg-+Lepr^db/+Lepr^db/OlaHsd db/db mice (Harlan Sprague–Dawley). Closed diamonds, vehicle control; closed squares, 25 mg/kg BI-78D3. Data shown as means ± SD (n = 5). *, P < 0.0003; **, P < 0.0001.