FIGURE 2.

Multiple sequence alignment of representative GABA_C, AChBP, GABA_A, glycine, and 5-HT_3A receptor subunits (GABA_C ρ₁ receptor subunit numbering). The binding loops A–F are indicated by lines above the alignment. The residues in the binding pocket shown in Fig. 2 are in solid boxes. Based on the secondary structure of AChBP, residues belonging to α-helices, β-sheets, and 3₁₀-helices are labeled with a, b, and n, respectively.