FIGURE 1.

(A) Structures of the platinum complexes. (B) Sequences of the synthetic oligodeoxyribonucleotides used in this study with their abbreviations. The top and bottom strands of each pair are designated top and bottom, respectively, in the text. The bold letters in the top strands of the duplexes indicate the location of the 1,3-intrastrand cross-link after modification of the oligodeoxyribonucleotides by transplatin in the way described in the experimental section; the bold letters in the bottom strands of these duplexes indicate the location of the sites that were involved in the interstrand cross-links after the linkage isomerization reaction was completed (see the text).