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. 2008 Jul 25;95(9):4228–4240. doi: 10.1529/biophysj.108.132894

FIGURE 4.

FIGURE 4

The interval distribution p(τ) (dashed lines) and the time-dependent elongation rate C(t) (solid lines) for the single-step (a), the two-step (b), and the three-step model (c). The parameters for the three-step model are kb = 1 s−1, ku = 1 s−1, ko = 0.2 s−1, and ke = 0.1 s−1, which gives the average elongation rate Ω0 = (1/kb + 1/Inline graphic + 1/ke)−1 = 1/21 s−1 and the effective on-rate Inline graphicko/(1 + ku/kb) = 0.1 s−1. The parameters for the two-step model are determined so that they behave similarly, i.e., the on-rate kon = Inline graphic and the elongation rate in the on-state Inline graphic for the two-step model given by Inline graphic = (1/Ω0 – 1/Inline graphic)−1. The insets show the behaviors at t ≈ 0 with the asymptotic curves (dotted lines).