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Effects of RyR1 channel modulators on natrin inhibition of [3H]ryanodine binding to skeletal SR vesicles. Equilibrium [3H]ryanodine binding experiments, in different redox states (A), or in presence of channel activators (B) or channel inhibitors (C), were performed both with and without 3 μM natrin. Experimental conditions were the same as in Fig. 2. Data are presented as mean ± SD.
