FIGURE 8.

Effects of heterocellular electrical coupling during pacing in 2D monolayers and simulations. (A) Experimental CV versus myofibroblast coupling coefficient for pacing at 3 (diamonds) and 4 Hz (triangles). Three levels of myofibroblast coupling were achieved using Cx43 siRNA treated myofibroblasts (silenced), control myofibroblasts and Cx43 overexpressed myofibroblasts (overexpressed). (B) Numerical results for CV versus myofibroblast coupling coefficient for pacing at 3 and 4 Hz. All simulations and experiments were performed for a myofibroblast/myocyte area ratio of 0.25.