Table 4.

Apoptosis-related factors in DCIS and DCIS-Mi

	DCIS	DCIS-Mi	P-value
Apoptotic Index (N/1000)	1.7 ± 0.4	2.9 ± 0.6	0.082
Bcl-2
negative	21 (41.2%)	6 (21.4%)	0.071
Positive	30 (58.8%)	22 (78.6%)
Bax
negative	15 (28.8%)	1 (3.6%)	0.0028
Positive	37 (71.2%)	27 (96.4%)
Survivin
negative	23 (44.2%)	4 (14.3%)	0.0048
positive	29 (55.8%)	24 (85.7%)
p53
positive	39 (76.5%)	23 (82.1%)	0.55
Negative	12 (23.5%)	5 (17.9%)
p21
positive	36 (69.2%)	15 (53.6%)	0.17
negative	16 (30.8%)	13 (46.4%)
cyclinD1
positive	36 (70.6%)	18 (64.3%)	0.57
Negative	15 (29.4%)	10 (35.7%)
Rb
positive	35 (68.6%)	23 (82.1%)	0.18
negative	16 (31.4%)	5 (17.9%)

DCIS = ductal carcinoma in situ; DCIS-Mi = ductal carcinoma in situ with microinvasion.