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. 2008 Oct 24;3(10):e3524. doi: 10.1371/journal.pone.0003524

Figure 5. The epitope recognized by inhibitory llama antibodies maps to the TcTS catalytic site.

Figure 5

View of the TcTS active site shown as surface representation using the program Chimera. (A) Free TcTS, (B) DANA-TcTS (shows the conformational change upon binding of DANA to TcTS) and (C) shows a 90° rotation of TcTS-DANA structure highlighting the arginine 311 residue protruding from the active site. PDBs used are 1MS4 and 1MS8. Residues involved in the catalytic site are colored as follows: mutated residues that were analyzed in this work (Trp312 and Tyr119) in red, other catalytic amino acids (Arg35, Asp59, Asp96, Met98, Arg314, Arg245, Glu230 and Tyr342) in yellow, space-fill model of DANA in green and Arg311 in blue.